8QF8

GH146 beta-L-arabinofuranosidase from Bacteroides thetaioatomicron in complex with beta-l-arabinofurano cyclophellitol aziridine

Summary for 8QF8

• Entry DOI: 10.2210/pdb8qf8/pdb
• Related: 8QF2
• Descriptor: Glycosyl hydrolase, (1~{S},2~{S},3~{S},4~{R})-4-azanyl-3-(hydroxymethyl)cyclopentane-1,2-diol, ZINC ION, ... (5 entities in total)
• Functional Keywords: btgh146, inhibitors, fluorescent probes, hydrolase
• Biological source: Bacteroides thetaiotaomicron
• Total number of polymer chains: 2
• Total formula weight: 183348.24

Authors

Borlandelli, V.,Offen, W.,Moroz, O.V.,Nin-Hill, A.,McGregor, N.,Binkhorst, L.,Armstrong, Z.,Ishiwata, A.,Artola, M.,Rovira, C.,Davies, G.J.,Overkleeft, H. (deposition date: 2023-09-04, release date: 2023-12-13, Last modification date: 2023-12-27)

• Primary citation: Borlandelli, V.,Offen, W.,Moroz, O.,Nin-Hill, A.,McGregor, N.,Binkhorst, L.,Ishiwata, A.,Armstrong, Z.,Artola, M.,Rovira, C.,Davies, G.J.,Overkleeft, H.S.; beta-l- Arabino furano-cyclitol Aziridines Are Covalent Broad-Spectrum Inhibitors and Activity-Based Probes for Retaining beta-l-Arabinofuranosidases.; Acs Chem.Biol., 18:2564-2573, 2023; PubMed: 38051515; DOI: 10.1021/acschembio.3c00558

Experimental method

X-RAY DIFFRACTION (2.4 Å)