8QAR
Crystal Structure of the first bromodomain of BRD4 in complex with acetyl-pyrrole derivative compound 98
Summary for 8QAR
Entry DOI | 10.2210/pdb8qar/pdb |
Related | 7QZB 8QAL 8QAN 8QAP |
Descriptor | Bromodomain-containing protein 4, 3-methyl-1-[2-[4-[(4-methyl-1~{H}-pyrazol-3-yl)methyl]piperazin-1-yl]-1,3-thiazol-4-yl]-2,5,6,7-tetrahydroisoindol-4-one, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | four helical bundle, transcription |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 15634.05 |
Authors | |
Primary citation | Cazzanelli, G.,Dalle Vedove, A.,Caflisch, A.,Lolli, G. Dual BET/BRPF1 inhibitors induce morphological alteration and cellular death in various human cancer cell lines To be published, |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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