8Q9Z

Cryo-EM structure of Cx26 gap junction K125E mutant in bicarbonate buffer (classification on hemichannel)

Summary for 8Q9Z

• Entry DOI: 10.2210/pdb8q9z/pdb
• EMDB information: 18290
• Descriptor: Gap junction beta-2 protein, DODECYL-BETA-D-MALTOSIDE, PHOSPHATIDYLETHANOLAMINE, ... (4 entities in total)
• Functional Keywords: gap junction large pore channel carbon dioxide sensitive, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 12
• Total formula weight: 349094.44

Authors

Brotherton, D.H.,Cameron, A.D. (deposition date: 2023-08-22, release date: 2024-06-12, Last modification date: 2024-06-19)

• Primary citation: Brotherton, D.H.,Nijjar, S.,Savva, C.G.,Dale, N.,Cameron, A.D.; Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO 2.; Elife, 13:-, 2024; PubMed: 38829031; DOI: 10.7554/eLife.93686

Experimental method

ELECTRON MICROSCOPY (2.4 Å)