8Q9P

Crystal Structure of the MADS-box/MEF2 Domain of MEF2D bound to dsDNA and HDAC5 deacetylase binding motif

8Q9P の概要

• エントリーDOI: 10.2210/pdb8q9p/pdb
• 分子名称: HDAC5 (histone deacetylase 5) binding motif peptide: TRP-GLY-SER-GLY-GLU-VAL-LYS-LEU-ARG-LEU-GLN-GLU-PHE-LEU-LEU-SER-LYS-SER, MEF2D protein, MADS box dsDNA fw: AACTATTTATAAGA, ... (5 entities in total)
• 機能のキーワード: transcriptional repressor, transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 33144.13

構造登録者

Chinellato, M.,Carli, A.,Perin, S.,Mazzocato, Y.,Biondi, B.,Di Giorgio, E.,Brancolini, C.,Angelini, A.,Cendron, L. (登録日: 2023-08-20, 公開日: 2024-04-17)

• 主引用文献: Chinellato, M.,Perin, S.,Carli, A.,Lastella, L.,Biondi, B.,Borsato, G.,Di Giorgio, E.,Brancolini, C.,Cendron, L.,Angelini, A.; Folding of Class IIa HDAC Derived Peptides into alpha-helices Upon Binding to Myocyte Enhancer Factor-2 in Complex with DNA.; J.Mol.Biol., 436:168541-168541, 2024; PubMed: 38492719; DOI: 10.1016/j.jmb.2024.168541

実験手法

X-RAY DIFFRACTION (2.2 Å)