8Q9N

Crystal Structure of the MADS-box/MEF2 Domain of MEF2D bound to dsDNA and MITR deacetylase binding motif mutant L151V.

Summary for 8Q9N

Entry DOI	10.2210/pdb8q9n/pdb
Descriptor	MEF2D protein, DNA MADS box, myocyte enhancer-binding factor 2-interacting transcriptional repressor (MITR or HDAC9) L151V mutant peptide: GLU-VAL-LYS-GLN-LYS-LEU-GLN-GLU-PHE-VAL-LEU-SER-LYS, ... (6 entities in total)
Functional Keywords	transcriptional repressor, transcription
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	33221.23
Authors	Chinellato, M.,Carli, A.,Perin, S.,Mazzocato, Y.,Biondi, B.,Di Giorgio, E.,Brancolini, C.,Angelini, A.,Cendron, L. (deposition date: 2023-08-20, release date: 2024-06-26)
Primary citation	Chinellato, M.,Perin, S.,Carli, A.,Lastella, L.,Biondi, B.,Borsato, G.,Di Giorgio, E.,Brancolini, C.,Cendron, L.,Angelini, A. Folding of Class IIa HDAC Derived Peptides into alpha-helices Upon Binding to Myocyte Enhancer Factor-2 in Complex with DNA. J.Mol.Biol., 436:168541-168541, 2024 Cited by PubMed: 38492719 DOI: 10.1016/j.jmb.2024.168541 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.51 Å)

Structure validation