8Q7O

Crystal structure of the FZD3 cysteine-rich domain in complex with a nanobody (14478)

Summary for 8Q7O

Entry DOI	10.2210/pdb8q7o/pdb
Descriptor	Nanobody 14478, Frizzled-3, DIMETHYL SULFOXIDE, ... (8 entities in total)
Functional Keywords	frizzled, wnt, gpcr, nanobody, complex, signaling protein
Biological source	Lama glama More
Total number of polymer chains	4
Total formula weight	56789.86
Authors	Hillier, J.S.,Zhao, Y.,Malinauskas, T.,Jones, E.Y. (deposition date: 2023-08-16, release date: 2024-08-28, Last modification date: 2024-09-04)
Primary citation	Hillier, J.,Zhao, Y.,Carrique, L.,Malinauskas, T.,Ruza, R.R.,Chang, T.H.,Yi, G.,Duyvesteyn, H.M.E.,Yu, J.,Lu, W.,Pardon, E.,Steyaert, J.,Zhu, Y.,Ni, T.,Jones, E.Y. Structural insights into Frizzled3 through nanobody modulators. Nat Commun, 15:7228-7228, 2024 Cited by PubMed: 39174501 DOI: 10.1038/s41467-024-51451-1 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.76 Å)

Structure validation