8Q7H

Structure of CUL9-RBX1 ubiquitin E3 ligase complex in unneddylated and neddylated conformation - focused cullin dimer

Summary for 8Q7H

• Entry DOI: 10.2210/pdb8q7h/pdb
• Related: 8Q7E
• EMDB information: 18216 18217 18218 18220 18221 18222 18223
• Descriptor: Cullin-9, E3 ubiquitin-protein ligase RBX1, NEDD8, ... (5 entities in total)
• Functional Keywords: cullin-ring rbr e3 ligase, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 610561.58

Authors

Hopf, L.V.M.,Horn-Ghetko, D.,Schulman, B.A. (deposition date: 2023-08-16, release date: 2024-04-17, Last modification date: 2024-04-24)

• Primary citation: Horn-Ghetko, D.,Hopf, L.V.M.,Tripathi-Giesgen, I.,Du, J.,Kostrhon, S.,Vu, D.T.,Beier, V.,Steigenberger, B.,Prabu, J.R.,Stier, L.,Bruss, E.M.,Mann, M.,Xiong, Y.,Schulman, B.A.; Noncanonical assembly, neddylation and chimeric cullin-RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex.; Nat.Struct.Mol.Biol., 2024; PubMed: 38605244; DOI: 10.1038/s41594-024-01257-y

Experimental method

ELECTRON MICROSCOPY (4.1 Å)