8Q34

Crystal structure of the first bromodomain of human BRD4 in complex with the ligand ZZ001229a

Summary for 8Q34

Entry DOI	10.2210/pdb8q34/pdb
Descriptor	Bromodomain-containing protein 4, 1,2-ETHANEDIOL, ~{N}-(1~{H}-imidazo[4,5-b]pyridin-2-ylmethyl)-3-(3-methyl-1,2-diazirin-3-yl)propanamide, ... (4 entities in total)
Functional Keywords	ligand complex, bromodomain, covalent, gene regulation
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	63052.41
Authors	MacLean, E.M.,Gao, Q.,Williams, E.,Balcomb, B.H.,von Delft, F.,Bajusz, D.,Keeley, A.,Abranyi-Balogh, P.,Koekemoer, L.,Keseru, G.M. (deposition date: 2023-08-03, release date: 2024-02-07, Last modification date: 2024-08-14)
Primary citation	Abranyi-Balogh, P.,Bajusz, D.,Orgovan, Z.,Keeley, A.B.,Petri, L.,Peczka, N.,Szalai, T.V.,Palfy, G.,Gadanecz, M.,Grant, E.K.,Imre, T.,Takacs, T.,Randelovic, I.,Baranyi, M.,Marton, A.,Schlosser, G.,Ashraf, Q.F.,de Araujo, E.D.,Karancsi, T.,Buday, L.,Tovari, J.,Perczel, A.,Bush, J.T.,Keseru, G.M. Mapping protein binding sites by photoreactive fragment pharmacophores. Commun Chem, 7:168-168, 2024 Cited by PubMed: 39085342 DOI: 10.1038/s42004-024-01252-w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.48 Å)

Structure validation