8Q2G

X-ray structure of LysECD7 endolysin against Gram-negative bacteria

Summary for 8Q2G

• Entry DOI: 10.2210/pdb8q2g/pdb
• Descriptor: Peptidoglycan L-alanyl-D-glutamate endopeptidase (2 entities in total)
• Functional Keywords: endolysins, bacteriophage lytic enzymes, gram-negative bacteria, antibacterial therapy, antimicrobial agents, antibiotic, antimicrobial protein
• Biological source: Escherichia phage ECD7
• Total number of polymer chains: 1
• Total formula weight: 16117.48

Authors

Prudnikova, T.,Grinkevich, P.,Vasina, D.V. (deposition date: 2023-08-02, release date: 2024-07-31)

• Primary citation: Vasina, D.V.,Antonova, N.P.,Gushchin, V.A.,Aleshkin, A.V.,Fursov, M.V.,Fursova, A.D.,Gancheva, P.G.,Grigoriev, I.V.,Grinkevich, P.,Kondratev, A.V.,Kostarnoy, A.V.,Lendel, A.M.,Makarov, V.V.,Nikiforova, M.A.,Pochtovyi, A.A.,Prudnikova, T.,Remizov, T.A.,Shevlyagina, N.V.,Siniavin, A.E.,Smirnova, N.S.,Terechov, A.A.,Tkachuk, A.P.,Usachev, E.V.,Vorobev, A.M.,Yakimakha, V.S.,Yudin, S.M.,Zackharova, A.A.,Zhukhovitsky, V.G.,Logunov, D.Y.,Gintsburg, A.L.; Development of novel antimicrobials with engineered endolysin LysECD7-SMAP to combat Gram-negative bacterial infections; J.Biomed.Sci., 31:75-, 2024; DOI: 10.1186/s12929-024-01065-y

Experimental method

X-RAY DIFFRACTION (2.49 Å)