8Q1H

LSD1 Y391K-CoREST bound to Histone H3 N-terminal tail

Summary for 8Q1H

Entry DOI	10.2210/pdb8q1h/pdb
Descriptor	Lysine-specific histone demethylase 1A, REST corepressor 1, Histone H3.3C, ... (4 entities in total)
Functional Keywords	histone code, demethylase, flavin, oxidoreductase
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	104539.49
Authors	Barone, M.,Mattevi, A. (deposition date: 2023-07-31, release date: 2024-05-15, Last modification date: 2024-07-17)
Primary citation	Lee, K.,Barone, M.,Waterbury, A.L.,Jiang, H.,Nam, E.,DuBois-Coyne, S.E.,Whedon, S.D.,Wang, Z.A.,Caroli, J.,Neal, K.,Ibeabuchi, B.,Dhoondia, Z.,Kuroda, M.I.,Liau, B.B.,Beck, S.,Mattevi, A.,Cole, P.A. Uncoupling histone modification crosstalk by engineering lysine demethylase LSD1. Nat.Chem.Biol., 2024 Cited by PubMed: 38965385 DOI: 10.1038/s41589-024-01671-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation