8PZ9

Crystal structure of VDR in complex with D-Bishomo-1a,25-dihydroxyvitamin D3 Analog 55

Summary for 8PZ9

• Entry DOI: 10.2210/pdb8pz9/pdb
• Descriptor: Vitamin D3 receptor A, Nuclear receptor coactivator 2, (1~{R},3~{R})-5-[(2~{E})-2-[(4~{a}~{R},5~{R},9~{a}~{S})-4~{a}-methyl-5-[(2~{R})-6-methyl-6-oxidanyl-heptan-2-yl]-3,4,5,8,9,9~{a}-hexahydro-2~{H}-benzo[7]annulen-1-ylidene]ethylidene]-2-methylidene-cyclohexane-1,3-diol, ... (4 entities in total)
• Functional Keywords: nuclear receptor, vdr, agonist, transcription
• Biological source: Danio rerio (zebrafish); More
• Total number of polymer chains: 2
• Total formula weight: 36085.23

Authors

Rochel, N. (deposition date: 2023-07-27, release date: 2023-08-30, Last modification date: 2024-04-24)

• Primary citation: Fabisiak, A.,Brzeminski, P.,Sicinski, R.R.,Rochel, N.,Maj, E.,Filip-Psurska, B.,Wietrzyk, J.,Plum, L.A.,DeLuca, H.F.; Design, synthesis, and biological activity of D-bishomo-1 alpha ,25-dihydroxyvitamin D 3 analogs and their crystal structures with the vitamin D nuclear receptor.; Eur.J.Med.Chem., 271:116403-116403, 2024; PubMed: 38615411; DOI: 10.1016/j.ejmech.2024.116403

Experimental method

X-RAY DIFFRACTION (2.74 Å)