8PYW

Crystal structure of the human Nucleoside-diphosphate kinase B domain bound to compound diphosphate form of AT-9052-Sp.

8PYW の概要

• エントリーDOI: 10.2210/pdb8pyw/pdb
• 分子名称: Nucleoside diphosphate kinase B, GLYCEROL, [[(2R,3R,4R,5R)-5-(2-azanyl-6-oxidanylidene-1H-purin-9-yl)-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methoxy-sulfanyl-phosphoryl] dihydrogen phosphate, ... (4 entities in total)
• 機能のキーワード: transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 106627.46

構造登録者

Feracci, M.,Chazot, A. (登録日: 2023-07-26, 公開日: 2023-12-27, 最終更新日: 2024-02-21)

• 主引用文献: Shannon, A.,Chazot, A.,Feracci, M.,Falcou, C.,Fattorini, V.,Selisko, B.,Good, S.,Moussa, A.,Sommadossi, J.P.,Ferron, F.,Alvarez, K.,Canard, B.; An exonuclease-resistant chain-terminating nucleotide analogue targeting the SARS-CoV-2 replicase complex.; Nucleic Acids Res., 52:1325-1340, 2024; PubMed: 38096103; DOI: 10.1093/nar/gkad1194

実験手法

X-RAY DIFFRACTION (1.553 Å)