8PWH

Atomic structure and conformational variability of the HER2-Trastuzumab-Pertuzumab complex

Summary for 8PWH

Entry DOI	10.2210/pdb8pwh/pdb
EMDB information	17993
Descriptor	Trastuzumab Fab light chain, Trastuzumab Fab heavy chain, Pertuzumab Fab light chain, ... (7 entities in total)
Functional Keywords	erbb-2, pertuzumab, trastuzumab, ternary complex, protein, flexibility, continuous conformation, cryo-em, single particle analysis, structural protein
Biological source	Homo sapiens More
Total number of polymer chains	5
Total formula weight	164744.64
Authors	Ruedas, R.,Vuillemot, R.,Tubiana, T.,Winter, J.M.,Pieri, L.,Arteni, A.A.,Samson, C.,Jonic, J.,Mathieu, M.,Bressanelli, S. (deposition date: 2023-07-20, release date: 2024-02-21, Last modification date: 2024-05-22)
Primary citation	Ruedas, R.,Vuillemot, R.,Tubiana, T.,Winter, J.M.,Pieri, L.,Arteni, A.A.,Samson, C.,Jonic, S.,Mathieu, M.,Bressanelli, S. Structure and conformational variability of the HER2-trastuzumab-pertuzumab complex. J.Struct.Biol., 216:108095-108095, 2024 Cited by PubMed: 38723875 DOI: 10.1016/j.jsb.2024.108095 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.17 Å)

Structure validation