8PWH

Atomic structure and conformational variability of the HER2-Trastuzumab-Pertuzumab complex

8PWH の概要

• エントリーDOI: 10.2210/pdb8pwh/pdb
• EMDBエントリー: 17993
• 分子名称: Trastuzumab Fab light chain, Trastuzumab Fab heavy chain, Pertuzumab Fab light chain, ... (7 entities in total)
• 機能のキーワード: erbb-2, pertuzumab, trastuzumab, ternary complex, protein, flexibility, continuous conformation, cryo-em, single particle analysis, structural protein
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 164744.64

構造登録者

Ruedas, R.,Vuillemot, R.,Tubiana, T.,Winter, J.M.,Pieri, L.,Arteni, A.A.,Samson, C.,Jonic, J.,Mathieu, M.,Bressanelli, S. (登録日: 2023-07-20, 公開日: 2024-02-21, 最終更新日: 2024-05-22)

• 主引用文献: Ruedas, R.,Vuillemot, R.,Tubiana, T.,Winter, J.M.,Pieri, L.,Arteni, A.A.,Samson, C.,Jonic, S.,Mathieu, M.,Bressanelli, S.; Structure and conformational variability of the HER2-trastuzumab-pertuzumab complex.; J.Struct.Biol., 216:108095-108095, 2024; PubMed: 38723875; DOI: 10.1016/j.jsb.2024.108095

実験手法

ELECTRON MICROSCOPY (3.17 Å)