8PRY
Crystal structure of Trypanosoma cruzi glycerol kinase
Summary for 8PRY
| Entry DOI | 10.2210/pdb8pry/pdb |
| Descriptor | glycerol kinase, GLYCEROL (3 entities in total) |
| Functional Keywords | glycerol metabolism, trypanosoma cruzi, glycosomes., transferase |
| Biological source | Trypanosoma cruzi |
| Total number of polymer chains | 4 |
| Total formula weight | 233449.02 |
| Authors | Lipinski, O.,Sonani, R.R.,Dubin, G. (deposition date: 2023-07-12, release date: 2024-07-24, Last modification date: 2025-02-05) |
| Primary citation | Lipinski, O.,Sonani, R.R.,Dubin, G. Crystal structure of glycerol kinase from Trypanosoma cruzi, a potential molecular target in Chagas disease. Acta Crystallogr D Struct Biol, 80:629-638, 2024 Cited by PubMed Abstract: Chagas disease is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. It bears a significant global health burden with limited treatment options, thus calling for the development of new and effective drugs. Certain trypanosomal metabolic enzymes have been suggested to be druggable and valid for subsequent inhibition. In this study, the crystal structure of glycerol kinase from T. cruzi, a key enzyme in glycerol metabolism in this parasite, is presented. Structural analysis allowed a detailed description of the glycerol binding pocket, while comparative assessment pinpointed a potential regulatory site which may serve as a target for selective inhibition. These findings advance the understanding of glycerol metabolism in eukaryotes and provide a solid basis for the future treatment of Chagas disease. PubMed: 39052317DOI: 10.1107/S2059798324006594 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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