8PQN

NQO1 bound to RBS-10

8PQN の概要

• エントリーDOI: 10.2210/pdb8pqn/pdb
• 分子名称: NAD(P)H dehydrogenase [quinone] 1, FLAVIN-ADENINE DINUCLEOTIDE, ~{N}-[4-[(3-methylphenyl)carbonylamino]phenyl]-5-nitro-furan-2-carboxamide (3 entities in total)
• 機能のキーワード: nqo1, rbs-10, quinone reductase, degrader resistance, prodrug, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 125407.43

構造登録者

Pous, J.,Jose-Duran, F.,Mayor-Ruiz, C.,Riera, A. (登録日: 2023-07-11, 公開日: 2024-01-10, 最終更新日: 2024-03-20)

• 主引用文献: Barbosa, B.M.G.,Sfyaki, A.,Rafael, S.,Jose-Duran, F.,Pous, J.,Sanchez-Zarzalejo, C.,Perez-Lopez, C.,Vilanova, M.,Cigler, M.,Gay, M.,Vilaseca, M.,Winter, G.E.,Riera, A.,Mayor-Ruiz, C.; Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders.; Angew.Chem.Int.Ed.Engl., 63:e202316730-e202316730, 2024; PubMed: 38153885; DOI: 10.1002/anie.202316730

実験手法

X-RAY DIFFRACTION (3.8 Å)