8PPN
Galectin-3 carbohydrate recognition domain in complex with thiodigalactoside at 1.8 resolution
Summary for 8PPN
| Entry DOI | 10.2210/pdb8ppn/pdb |
| Related | 8OJI |
| Related PRD ID | PRD_900027 |
| Descriptor | Galectin-3, 1-thio-beta-D-galactopyranose-(1-1)-beta-D-galactopyranose, CHLORIDE ION, ... (5 entities in total) |
| Functional Keywords | sugar binding protein |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 16186.96 |
| Authors | Tsagkarakou, A.S.,Leonidas, D.D. (deposition date: 2023-07-07, release date: 2023-09-13, Last modification date: 2023-09-20) |
| Primary citation | Lazar, L.,Tsagkarakou, A.S.,Stravodimos, G.,Kontopidis, G.,Leffler, H.,Nilsson, U.J.,Somsak, L.,Leonidas, D.D. Strong Binding of C -Glycosylic1,2-Thiodisaccharides to Galectin-3─Enthalpy-Driven Affinity Enhancement by Water-Mediated Hydrogen Bonds. J.Med.Chem., 66:12420-12431, 2023 Cited by PubMed: 37658813DOI: 10.1021/acs.jmedchem.3c00882 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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