8POT

Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and the benzoxaborole cmpd9 in the editing conformation

Summary for 8POT

Entry DOI	10.2210/pdb8pot/pdb
Related	8POQ 8POR 8POS
Descriptor	Leucine--tRNA ligase, tRNA(leu), 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	leucine trna ligase, atp binding protein, trna aminoacylation for protein translation, cytosolic reaction catalysed: atp + l-leucine + trna(leu) = amp + diphosphate + l-leucyl-trna(leu), ligase
Biological source	Escherichia coli K-12 More
Total number of polymer chains	2
Total formula weight	128440.12
Authors	Palencia, A.,Hoffmann, G. (deposition date: 2023-07-05, release date: 2024-06-12, Last modification date: 2024-07-24)
Primary citation	Hoffmann, G.,Lukarska, M.,Clare, R.H.,Masters, E.K.G.,Johnston, K.L.,Ford, L.,Turner, J.D.,Ward, S.A.,Taylor, M.J.,Jensen, M.R.,Palencia, A. Targeting a microbiota Wolbachian aminoacyl-tRNA synthetase to block its pathogenic host. Sci Adv, 10:eado1453-eado1453, 2024 Cited by PubMed: 38985862 DOI: 10.1126/sciadv.ado1453 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.149 Å)

Structure validation