8PON

TEAD2 in complex with an inhibitor

Summary for 8PON

Entry DOI	10.2210/pdb8pon/pdb
Related	8P29 8POJ 8POM
Descriptor	Transcriptional enhancer factor TEF-4, MYRISTIC ACID, 4-fluoranyl-2-[(3-phenylmethoxyphenyl)amino]benzoic acid, ... (4 entities in total)
Functional Keywords	inhibitor, tead, complex, signaling protein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	55543.91
Authors	Guichou, J.F. (deposition date: 2023-07-05, release date: 2023-11-22)
Primary citation	Fnaiche, A.,Melin, L.,Suarez, N.G.,Paquin, A.,Vu, V.,Li, F.,Allali-Hassani, A.,Bolotokova, A.,Allemand, F.,Gelin, M.,Cotelle, P.,Woo, S.,LaPlante, S.R.,Barsyte-Lovejoy, D.,Santhakumar, V.,Vedadi, M.,Guichou, J.F.,Annabi, B.,Gagnon, A. Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings. Bioorg.Med.Chem.Lett., 95:129488-129488, 2023 Cited by PubMed: 37770003 DOI: 10.1016/j.bmcl.2023.129488 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation