8PKG

ATTRV122I amyloid fibril from hereditary ATTR amloidosis

Summary for 8PKG

Entry DOI	10.2210/pdb8pkg/pdb
EMDB information	17738
Descriptor	Transthyretin (1 entity in total)
Functional Keywords	transthyretin, attr amyloidosis, attrv122i, amyloid fibril, misfolding disease, cryo-em, protein fibril
Biological source	Homo sapiens (human)
Total number of polymer chains	6
Total formula weight	82748.32
Authors	Steinebrei, M.,Schmidt, M.,Faendrich, M. (deposition date: 2023-06-26, release date: 2023-12-06)
Primary citation	Steinebrei, M.,Baur, J.,Pradhan, A.,Kupfer, N.,Wiese, S.,Hegenbart, U.,Schonland, S.O.,Schmidt, M.,Fandrich, M. Common transthyretin-derived amyloid fibril structures in patients with hereditary ATTR amyloidosis. Nat Commun, 14:7623-7623, 2023 Cited by PubMed: 37993462 DOI: 10.1038/s41467-023-43301-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.99 Å)

Structure validation