8PJ8

FKBP51FK1 F67E/K60Orn (i, i+7) in complex with SAFit1

Summary for 8PJ8

• Entry DOI: 10.2210/pdb8pj8/pdb
• Descriptor: Peptidyl-prolyl cis-trans isomerase FKBP5, 2-[3-[(1~{R})-1-[(2~{S})-1-[(2~{S})-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)ethanoyl]piperidin-2-yl]carbonyloxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]ethanoic acid (3 entities in total)
• Functional Keywords: fkbp51fk1, safit1, inhibitor, lactambridge, isomerase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 14682.73

Authors

Meyners, C.,Charalampidou, A.,Hausch, F. (deposition date: 2023-06-23, release date: 2024-03-06, Last modification date: 2024-04-10)

• Primary citation: Charalampidou, A.,Nehls, T.,Meyners, C.,Gandhesiri, S.,Pomplun, S.,Pentelute, B.L.,Lermyte, F.,Hausch, F.; Automated Flow Peptide Synthesis Enables Engineering of Proteins with Stabilized Transient Binding Pockets.; Acs Cent.Sci., 10:649-657, 2024; PubMed: 38559286; DOI: 10.1021/acscentsci.3c01283

Experimental method

X-RAY DIFFRACTION (1.5 Å)