8PJ8
FKBP51FK1 F67E/K60Orn (i, i+7) in complex with SAFit1
Summary for 8PJ8
Entry DOI | 10.2210/pdb8pj8/pdb |
Descriptor | Peptidyl-prolyl cis-trans isomerase FKBP5, 2-[3-[(1~{R})-1-[(2~{S})-1-[(2~{S})-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)ethanoyl]piperidin-2-yl]carbonyloxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]ethanoic acid (3 entities in total) |
Functional Keywords | fkbp51fk1, safit1, inhibitor, lactambridge, isomerase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 14682.73 |
Authors | Meyners, C.,Charalampidou, A.,Hausch, F. (deposition date: 2023-06-23, release date: 2024-03-06, Last modification date: 2024-04-10) |
Primary citation | Charalampidou, A.,Nehls, T.,Meyners, C.,Gandhesiri, S.,Pomplun, S.,Pentelute, B.L.,Lermyte, F.,Hausch, F. Automated Flow Peptide Synthesis Enables Engineering of Proteins with Stabilized Transient Binding Pockets. Acs Cent.Sci., 10:649-657, 2024 Cited by PubMed: 38559286DOI: 10.1021/acscentsci.3c01283 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
Download full validation report