8PEQ
Complex of diubiquitin-derived artificial binding protein (Affilin) variant Af2 with its target oncofetal fibronectin (fragment 7B8)
Summary for 8PEQ
Entry DOI | 10.2210/pdb8peq/pdb |
Descriptor | Fibronectin, Affilin variant Af2, SULFATE ION, ... (4 entities in total) |
Functional Keywords | extra domain b, edb, oncofetal fibronectin, ubiquitin, diubiqutin, affilin, beta strand register shift, strand slippage, scaffold, artificial binding protein, plasticity, directed evolution, de novo protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 141905.20 |
Authors | Parthier, C.,Katzschmann, A.,Fiedler, E.,Haupts, U.,Reimann, A. (deposition date: 2023-06-14, release date: 2024-06-26, Last modification date: 2024-08-14) |
Primary citation | Katzschmann, A.,Haupts, U.,Reimann, A.,Settele, F.,Gloser-Braunig, M.,Fiedler, E.,Parthier, C. Ubiquitin-derived artificial binding proteins targeting oncofetal fibronectin reveal scaffold plasticity by beta-strand slippage. Commun Biol, 7:907-907, 2024 Cited by PubMed: 39068227DOI: 10.1038/s42003-024-06569-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.32 Å) |
Structure validation
Download full validation report