8PE9

Complex between DDR1 DS-like domain and PRTH-101 Fab

Summary for 8PE9

Entry DOI	10.2210/pdb8pe9/pdb
Descriptor	Epithelial discoidin domain-containing receptor 1, PRTH-101 Fab, heavy chain, PRTH-101 Fab, light chain, ... (8 entities in total)
Functional Keywords	humanized antibody, ddr1, collagen, immune exclusion, breast cancer, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	68074.07
Authors	Liu, J.,Chiang, H.,Xiong, W.,Laurent, V.,Griffiths, S.C.,Duelfer, J.,Deng, H.,Sun, X.,Yin, Y.W.,Li, W.,Audoly, L.P.,An, Z.,Schuerpf, T.,Li, R.,Zhang, N. (deposition date: 2023-06-13, release date: 2023-06-28, Last modification date: 2024-02-07)
Primary citation	Liu, J.,Chiang, H.C.,Xiong, W.,Laurent, V.,Griffiths, S.C.,Dulfer, J.,Deng, H.,Sun, X.,Yin, Y.W.,Li, W.,Audoly, L.P.,An, Z.,Schurpf, T.,Li, R.,Zhang, N. A highly selective humanized DDR1 mAb reverses immune exclusion by disrupting collagen fiber alignment in breast cancer. J Immunother Cancer, 11:-, 2023 Cited by PubMed: 37328286 DOI: 10.1136/jitc-2023-006720 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.152 Å)

Structure validation