8PDH

The phosphatase and C2 domains of SHIP1 with covalent Z1742148362

This is a non-PDB format compatible entry.

Summary for 8PDH

• Entry DOI: 10.2210/pdb8pdh/pdb
• Descriptor: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1, (5-phenyl-1,3,4-oxadiazol-2-yl)methanimine, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: ligand, phoshphatase, c2, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 53347.21

Authors

Bradshaw, W.J.,Moreira, T.,Pascoa, T.C.,Bountra, C.,Chalk, R.,von Delft, F.,Brennan, P.E.,Gileadi, O. (deposition date: 2023-06-12, release date: 2023-06-28, Last modification date: 2024-04-17)

• Primary citation: Bradshaw, W.J.,Kennedy, E.C.,Moreira, T.,Smith, L.A.,Chalk, R.,Katis, V.L.,Benesch, J.L.P.,Brennan, P.E.,Murphy, E.J.,Gileadi, O.; Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2.; Structure, 32:453-, 2024; PubMed: 38309262; DOI: 10.1016/j.str.2024.01.005

Experimental method

X-RAY DIFFRACTION (1.45 Å)