8PDF

FKBP12 in complex with PROTAC 6a2

8PDF の概要

• エントリーDOI: 10.2210/pdb8pdf/pdb
• 分子名称: Peptidyl-prolyl cis-trans isomerase FKBP1A, (2~{S},4~{R})-1-[(2~{S})-2-[2-[2-[2-[4-[(1~{S})-1-[(1~{S},5~{S},6~{R})-10-[3,5-bis(chloranyl)phenyl]sulfonyl-5-ethenyl-2-oxidanylidene-3,10-diazabicyclo[4.3.1]decan-3-yl]ethyl]-1,2,3-triazol-1-yl]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide (3 entities in total)
• 機能のキーワード: fkbp12, complex, protac, isomerase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12875.58

構造登録者

Meyners, C.,Walz, M.,Geiger, T.M.,Hausch, F. (登録日: 2023-06-12, 公開日: 2023-11-15, 最終更新日: 2024-01-24)

• 主引用文献: Geiger, T.M.,Walz, M.,Meyners, C.,Kuehn, A.,Dreizler, J.K.,Sugiarto, W.O.,Maciel, E.V.S.,Zheng, M.,Lermyte, F.,Hausch, F.; Discovery of a Potent Proteolysis Targeting Chimera Enables Targeting the Scaffolding Functions of FK506-Binding Protein 51 (FKBP51).; Angew.Chem.Int.Ed.Engl., 63:e202309706-e202309706, 2024; PubMed: 37942685; DOI: 10.1002/anie.202309706

実験手法

X-RAY DIFFRACTION (1.2 Å)