8PDA
cryo-EM structure of Doa10 with RING domain in MSP1E3D1
Summary for 8PDA
Entry DOI | 10.2210/pdb8pda/pdb |
EMDB information | 17608 |
Descriptor | ERAD-associated E3 ubiquitin-protein ligase DOA10, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE (3 entities in total) |
Functional Keywords | erad, doa10, march6, teb4, retrotranslocation, ubiquitination, ubc6, sybody, sqle, squalenemonooxygenase, ligase |
Biological source | Saccharomyces cerevisiae (baker's yeast) |
Total number of polymer chains | 1 |
Total formula weight | 154617.36 |
Authors | |
Primary citation | Botsch, J.J.,Junker, R.,Sorgenfrei, M.,Ogger, P.P.,Stier, L.,von Gronau, S.,Murray, P.J.,Seeger, M.A.,Schulman, B.A.,Brauning, B. Doa10/MARCH6 architecture interconnects E3 ligase activity with lipid-binding transmembrane channel to regulate SQLE. Nat Commun, 15:410-410, 2024 Cited by PubMed: 38195637DOI: 10.1038/s41467-023-44670-5 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.58 Å) |
Structure validation
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