8PD4
Crystal structure of TRIM58 PRY-SPRY domain
Summary for 8PD4
Entry DOI | 10.2210/pdb8pd4/pdb |
Descriptor | E3 ubiquitin-protein ligase TRIM58 (2 entities in total) |
Functional Keywords | e3 ligase, trim58, pry-spry, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 48469.13 |
Authors | Renatus, M.,Schroeder, M. (deposition date: 2023-06-11, release date: 2024-01-31, Last modification date: 2024-02-07) |
Primary citation | Hoegenauer, K.,An, S.,Axford, J.,Benander, C.,Bergsdorf, C.,Botsch, J.,Chau, S.,Fernandez, C.,Gleim, S.,Hassiepen, U.,Hunziker, J.,Joly, E.,Keller, A.,Lopez Romero, S.,Maher, R.,Mangold, A.S.,Mickanin, C.,Mihalic, M.,Neuner, P.,Patterson, A.W.,Perruccio, F.,Roggo, S.,Scesa, J.,Schroder, M.,Shkoza, D.,Thai, B.,Vulpetti, A.,Renatus, M.,Reece-Hoyes, J.S. Discovery of Ligands for TRIM58, a Novel Tissue-Selective E3 Ligase. Acs Med.Chem.Lett., 14:1631-1639, 2023 Cited by PubMed: 38116426DOI: 10.1021/acsmedchemlett.3c00259 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.714 Å) |
Structure validation
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