8PCC

Structure of serine-beta-lactamase CTX-M-14 following the time-resolved active site binding of boric acid, 100 ms

Summary for 8PCC

• Entry DOI: 10.2210/pdb8pcc/pdb
• Descriptor: Beta-lactamase, BORATE ION, SULFATE ION, ... (4 entities in total)
• Functional Keywords: catalytic activity, beta-lactamase activity, hydrolase activity, inhibitor, time-resolved, tape drive, hydrolase
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 1
• Total formula weight: 28175.45

Authors

Prester, A.,Perbandt, M.,Galchenkova, M.,Oberthuer, D.,Yefanov, O.,Hinrichs, W.,Rohde, H.,Betzel, C. (deposition date: 2023-06-11, release date: 2024-06-26)

• Primary citation: Prester, A.,Perbandt, M.,Galchenkova, M.,Oberthuer, D.,Werner, N.,Henkel, A.,Maracke, J.,Yefanov, O.,Hakanpaeae, J.,Pompidor, G.,Meyer, J.,Chapman, H.,Aepfelbacher, M.,Hinrichs, W.,Rohde, H.,Betzel, C.; Time resolved crystallography of boric acid binding to the active site serine of the beta-lactamase CTX-M-14 and subsequent 1,2-diol esterification; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.04 Å)