8P8E

Crystal structure of endolysin gp46 from Pseudomonas aeruginosa bacteriophage vB_PaeM_KTN6

これはPDB形式変換不可エントリーです。

8P8E の概要

• エントリーDOI: 10.2210/pdb8p8e/pdb
• 分子名称: Glycoside hydrolase family protein, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... (4 entities in total)
• 機能のキーワード: endolysin, phage lysozyme, muramidase, antimicrobial, hydrolase
• 由来する生物種: Bacteriophage sp.
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24782.15

構造登録者

van Raaij, M.J.,Sanz-Gaitero, M. (登録日: 2023-06-01, 公開日: 2024-05-08, 最終更新日: 2024-08-21)

主引用文献

Sanz-Gaitero, M.,De Maesschalck, V.,Patel, A.,Longin, H.,Van Noort, V.,Rodriguez-Rubio, L.,van Ryne, M.,Danis-Wlodarczyk, K.,Drulis-Kawa, Z.,Mesnage, S.,van Raaij, M.,Lavigne, R.
Structural and Biochemical Characterization of a New Phage-Encoded Muramidase, KTN6 Gp46.
Phage (New Rochelle), 5:53-62, 2024

PubMed Abstract: Endolysins are phage-encoded lytic enzymes that degrade bacterial peptidoglycan at the end of phage lytic cycles to release new phage particles. These enzymes are being explored as an alternative to small-molecule antibiotics.

PubMed: 39119210
DOI: 10.1089/phage.2023.0040

実験手法

X-RAY DIFFRACTION (1.391 Å)