8P81
Crystal structure of human Cdk12/Cyclin K in complex with inhibitor SR-4835
Summary for 8P81
Entry DOI | 10.2210/pdb8p81/pdb |
Descriptor | Cyclin-dependent kinase 12, Cyclin-K, ~{N}-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methyl]-9-(1-methylpyrazol-4-yl)-2-morpholin-4-yl-purin-6-amine, ... (4 entities in total) |
Functional Keywords | cyclin-dependent kinase, inhibitor, sr-4835, cdk12, cyclin k, transcription |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 72693.52 |
Authors | Anand, K.,Schmitz, M.,Geyer, M. (deposition date: 2023-05-31, release date: 2023-11-22, Last modification date: 2023-12-27) |
Primary citation | Schmitz, M.,Kaltheuner, I.H.,Anand, K.,Duster, R.,Moecking, J.,Monastyrskyi, A.,Duckett, D.R.,Roush, W.R.,Geyer, M. The reversible inhibitor SR-4835 binds Cdk12/cyclin K in a noncanonical G-loop conformation. J.Biol.Chem., 300:105501-105501, 2023 Cited by PubMed: 38016516DOI: 10.1016/j.jbc.2023.105501 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.68 Å) |
Structure validation
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