8P31

Structure of human SIT1:ACE2 complex (closed PD conformation) bound to L-pipecolate

Summary for 8P31

Entry DOI	10.2210/pdb8p31/pdb
EMDB information	17382
Descriptor	Processed angiotensin-converting enzyme 2, Sodium- and chloride-dependent transporter XTRP3, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywords	amino acid transporter, proline, slc6a20, ace2, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	335111.59
Authors	Li, H.Z.,Pike, A.C.W.,Chi, G.,Hansen, J.S.,Lee, S.G.,Rodstrom, K.E.J.,Bushell, S.R.,Speedman, D.,Evans, A.,Wang, D.,He, D.,Shrestha, L.,Nasrallah, C.,Chalk, R.,Moreira, T.,MacLean, E.M.,Marsden, B.,Bountra, C.,Burgess-Brown, N.A.,Dafforn, T.R.,Carpenter, E.P.,Sauer, D.B. (deposition date: 2023-05-16, release date: 2024-06-12, Last modification date: 2024-07-10)
Primary citation	Li, H.Z.,Pike, A.C.W.,Lotsaris, I.,Chi, G.,Hansen, J.S.,Lee, S.C.,Rodstrom, K.E.J.,Bushell, S.R.,Speedman, D.,Evans, A.,Wang, D.,He, D.,Shrestha, L.,Nasrallah, C.,Burgess-Brown, N.A.,Vandenberg, R.J.,Dafforn, T.R.,Carpenter, E.P.,Sauer, D.B. Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2. Nat Commun, 15:5503-5503, 2024 Cited by PubMed: 38951531 DOI: 10.1038/s41467-024-48921-x PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.24 Å)

Structure validation