8P2X

Structure of human SIT1:ACE2 complex (open PD conformation)

8P2X の概要

• エントリーDOI: 10.2210/pdb8p2x/pdb
• EMDBエントリー: 17378
• 分子名称: Processed angiotensin-converting enzyme 2, Sodium- and chloride-dependent transporter XTRP3, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: covid-19 receptor, amino acid transport, membrane protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 335265.57

構造登録者

Li, H.Z.,Pike, A.C.W.,Chi, G.,Hansen, J.S.,Lee, S.G.,Rodstrom, K.E.J.,Bushell, S.R.,Speedman, D.,Evans, A.,Wang, D.,He, D.,Shrestha, L.,Nasrallah, C.,Chalk, R.,Moreira, T.,MacLean, E.M.,Marsden, B.,Bountra, C.,Burgess-Brown, N.A.,Dafforn, T.R.,Carpenter, E.P.,Sauer, D.B. (登録日: 2023-05-16, 公開日: 2024-06-12, 最終更新日: 2024-07-10)

• 主引用文献: Li, H.Z.,Pike, A.C.W.,Lotsaris, I.,Chi, G.,Hansen, J.S.,Lee, S.C.,Rodstrom, K.E.J.,Bushell, S.R.,Speedman, D.,Evans, A.,Wang, D.,He, D.,Shrestha, L.,Nasrallah, C.,Burgess-Brown, N.A.,Vandenberg, R.J.,Dafforn, T.R.,Carpenter, E.P.,Sauer, D.B.; Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2.; Nat Commun, 15:5503-5503, 2024; PubMed: 38951531; DOI: 10.1038/s41467-024-48921-x

実験手法

ELECTRON MICROSCOPY (3.59 Å)