8P2R
Human Aldose Reductase Mutant A299G/L300A in Complex with a Ligand with an IDD Structure (3-({[2-(carboxymethoxy)-4-fluorobenzoyl]amino}methyl)benzoic acid)
Summary for 8P2R
Entry DOI | 10.2210/pdb8p2r/pdb |
Descriptor | Aldo-keto reductase family 1 member B1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CITRIC ACID, ... (5 entities in total) |
Functional Keywords | human aldose reductase, har, aldo-keto-reductase, ligand, sar061, nadp+, diabetes, mutant a299g/l300a, transient pocket, oxidoreductase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 37125.06 |
Authors | |
Primary citation | Klee, L.-S.,Heine, A.,Klebe, G.,Scheer, F. Human Aldose Reductase Mutant A299G/L300A in Complex with a Ligand with an IDD Structure (3-({[2-(carboxymethoxy)-4-fluorobenzoyl]amino}methyl)benzoic acid) To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
Download full validation report