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8P2E

Homotypic interacting B1 fab bound to Chondroitin Sulfate A

Summary for 8P2E
Entry DOI10.2210/pdb8p2e/pdb
EMDB information17362
DescriptorB1 fab light, B1 fab heavy (2 entities in total)
Functional Keywordschondroitin sulfate a, sugar binding protein
Biological sourceHomo sapiens
More
Total number of polymer chains8
Total formula weight200327.50
Authors
Raghavan, S.S.R.,Dagil, R.,Wang, K.T.,Salanti, A. (deposition date: 2023-05-16, release date: 2024-06-05, Last modification date: 2025-07-02)
Primary citationVidal-Calvo, E.E.,Martin-Salazar, A.,Choudhary, S.,Dagil, R.,Raghavan, S.S.R.,Duvnjak, L.,Nordmaj, M.A.,Clausen, T.M.,Skafte, A.,Oberkofler, J.,Wang, K.,Agerbaek, M.O.,Loppke, C.,Jorgensen, A.M.,Ropac, D.,Mujollari, J.,Willis, S.,Garcias Lopez, A.,Miller, R.L.,Karlsson, R.T.G.,Goerdeler, F.,Chen, Y.H.,Colaco, A.R.,Wang, Y.,Lavstsen, T.,Martowicz, A.,Nelepcu, I.,Marzban, M.,Oo, H.Z.,Orum-Madsen, M.S.,Wang, Y.,Nielsen, M.A.,Clausen, H.,Wierer, M.,Wolf, D.,Gogenur, I.,Theander, T.G.,Al-Nakouzi, N.,Gustavsson, T.,Daugaard, M.,Salanti, A.
Tumor-agnostic cancer therapy using antibodies targeting oncofetal chondroitin sulfate.
Nat Commun, 15:7553-7553, 2024
Cited by
PubMed Abstract: Molecular similarities between embryonic and malignant cells can be exploited to target tumors through specific signatures absent in healthy adult tissues. One such embryonic signature tumors express is oncofetal chondroitin sulfate (ofCS), which supports disease progression and dissemination in cancer. Here, we report the identification and characterization of phage display-derived antibody fragments recognizing two distinct ofCS epitopes. These antibody fragments show binding affinity to ofCS in the low nanomolar range across a broad selection of solid tumor types in vitro and in vivo with minimal binding to normal, inflamed, or benign tumor tissues. Anti-ofCS antibody drug conjugates and bispecific immune cell engagers based on these targeting moieties disrupt tumor progression in animal models of human and murine cancers. Thus, anti-ofCS antibody fragments hold promise for the development of broadly effective therapeutic and diagnostic applications targeting human malignancies.
PubMed: 39215044
DOI: 10.1038/s41467-024-51781-0
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (3.2 Å)
Structure validation

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