8P29

TEAD2 in complex with an inhibitor

8P29 の概要

• エントリーDOI: 10.2210/pdb8p29/pdb
• 分子名称: Transcriptional enhancer factor TEF-4, MYRISTIC ACID, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: inhibitor, signaling protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 55632.04

構造登録者

Guichou, J.F.,Gelin, M.,Allemand, F. (登録日: 2023-05-15, 公開日: 2023-11-22)

• 主引用文献: Fnaiche, A.,Melin, L.,Suarez, N.G.,Paquin, A.,Vu, V.,Li, F.,Allali-Hassani, A.,Bolotokova, A.,Allemand, F.,Gelin, M.,Cotelle, P.,Woo, S.,LaPlante, S.R.,Barsyte-Lovejoy, D.,Santhakumar, V.,Vedadi, M.,Guichou, J.F.,Annabi, B.,Gagnon, A.; Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings.; Bioorg.Med.Chem.Lett., 95:129488-129488, 2023; PubMed: 37770003; DOI: 10.1016/j.bmcl.2023.129488

実験手法

X-RAY DIFFRACTION (2.06 Å)