8P1I
Single particle cryo-EM co-structure of Klebsiella pneumoniae AcrB with the BDM91288 efflux pump inhibitor at 2.97 Angstrom resolution
Summary for 8P1I
Entry DOI | 10.2210/pdb8p1i/pdb |
EMDB information | 17350 |
Descriptor | Efflux pump membrane transporter, 3-chloranyl-2,6-di(piperazin-4-ium-1-yl)quinoline, [(2~{R})-1-[[(2~{R})-2,3-bis(oxidanyl)propoxy]-oxidanyl-phosphoryl]oxy-3-undecanoyloxy-propan-2-yl] tricosanoate, ... (4 entities in total) |
Functional Keywords | efflux pump inhibitor, transmembrane binding, antibiotic resistance, transport protein |
Biological source | Klebsiella pneumoniae subsp. pneumoniae DSM 30104 = JCM 1662 = NBRC 14940 |
Total number of polymer chains | 3 |
Total formula weight | 345549.79 |
Authors | Boernsen, C.,Mueller, R.T.,Pos, K.M.,Frangakis, A.S. (deposition date: 2023-05-12, release date: 2024-01-17, Last modification date: 2024-01-31) |
Primary citation | Vieira Da Cruz, A.,Jimenez-Castellanos, J.C.,Bornsen, C.,Van Maele, L.,Compagne, N.,Pradel, E.,Muller, R.T.,Meurillon, V.,Soulard, D.,Piveteau, C.,Biela, A.,Dumont, J.,Leroux, F.,Deprez, B.,Willand, N.,Pos, K.M.,Frangakis, A.S.,Hartkoorn, R.C.,Flipo, M. Pyridylpiperazine efflux pump inhibitor boosts in vivo antibiotic efficacy against K. pneumoniae. Embo Mol Med, 16:93-111, 2024 Cited by PubMed: 38177534DOI: 10.1038/s44321-023-00007-9 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.97 Å) |
Structure validation
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