8P1I
Single particle cryo-EM co-structure of Klebsiella pneumoniae AcrB with the BDM91288 efflux pump inhibitor at 2.97 Angstrom resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | Efflux pump membrane transporter | polymer | 1056 | 114489.9 | 3 | UniProt (J2LW81) Pfam (PF00873) UniProt (by SIFTS) (A0A332Z023) In PDB | Klebsiella pneumoniae subsp. pneumoniae DSM 30104 = JCM 1662 = NBRC 14940 | |
| 2 | A | 3-chloranyl-2,6-di(piperazin-4-ium-1-yl)quinoline | non-polymer | 333.9 | 1 | Chemie (WQW) | |||
| 3 | B | [(2~{R})-1-[[(2~{R})-2,3-bis(oxidanyl)propoxy]-oxidanyl-phosphoryl]oxy-3-undecanoyloxy-propan-2-yl] tricosanoate | non-polymer | 751.0 | 1 | Chemie (WR6) | |||
| 4 | C | 1,2-DIOCTANOYL-SN-GLYCERO-3-[PHOSPHO-RAC-(1-GLYCEROL) | non-polymer | 497.5 | 2 | Chemie (PG8) |
Sequence modifications
A, B, C: 1 - 1048 (UniProt: J2LW81)
| PDB | External Database | Details |
|---|---|---|
| Leu 1049 | - | expression tag |
| Glu 1050 | - | expression tag |
| His 1051 | - | expression tag |
| His 1052 | - | expression tag |
| His 1053 | - | expression tag |
| His 1054 | - | expression tag |
| His 1055 | - | expression tag |
| His 1056 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 343469.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2080.0 | |
| All* | Total formula weight | 345549.8 |
