8P04

Crystal structure of human CLK1 in complex with Leucettinib-92

Summary for 8P04

Entry DOI	10.2210/pdb8p04/pdb
Descriptor	Dual specificity protein kinase CLK1, (4~{Z})-2-(1-adamantylamino)-4-(1,3-benzothiazol-6-ylmethylidene)-1~{H}-imidazol-5-one (3 entities in total)
Functional Keywords	kinase, typ1 inhibitor, clk1, leicettinib, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	39960.00
Authors	Kraemer, A.,Schroeder, M.,Meijer, L.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2023-05-09, release date: 2023-05-17, Last modification date: 2023-11-22)
Primary citation	Deau, E.,Lindberg, M.F.,Miege, F.,Roche, D.,George, N.,George, P.,Kramer, A.,Knapp, S.,Meijer, L. Leucettinibs, a Class of DYRK/CLK Kinase Inhibitors Inspired by the Marine Sponge Natural Product Leucettamine B. J.Med.Chem., 66:10694-10714, 2023 Cited by PubMed: 37487467 DOI: 10.1021/acs.jmedchem.3c00884 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation