8OXX

Transglutaminase 3 in complex with inhibitor Z-don and DH patient-derived Fab DH63-B02

8OXX の概要

• エントリーDOI: 10.2210/pdb8oxx/pdb
• 分子名称: Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain, D-PROLINE, METHYL L-LEUCINATE, ... (12 entities in total)
• 機能のキーワード: transglutaminase, tgm3, tg3, transglutaminase 3, enzyme, antibody, dermatitis herpetiformis, inhibitor, z-don, ighv3-9, iglv6-57, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 99261.31

構造登録者

Heggelund, J.E.,Sollid, L.M. (登録日: 2023-05-02, 公開日: 2023-10-18, 最終更新日: 2023-11-15)

• 主引用文献: Heggelund, J.E.,Das, S.,Stamnaes, J.,Iversen, R.,Sollid, L.M.; Autoantibody binding and unique enzyme-substrate intermediate conformation of human transglutaminase 3.; Nat Commun, 14:6216-6216, 2023; PubMed: 37798283; DOI: 10.1038/s41467-023-42004-z

実験手法

X-RAY DIFFRACTION (2.5 Å)