8OV6

Ternary structure of intramolecular bivalent glue degrader IBG1 bound to BRD4 and DCAF16:DDB1deltaBPB

Summary for 8OV6

• Entry DOI: 10.2210/pdb8ov6/pdb
• EMDB information: 17172
• Descriptor: DDB1deltaBPB, DDB1- and CUL4-associated factor 16, Bromodomain-containing protein 4, ... (5 entities in total)
• Functional Keywords: bromodomain, bet protein, dcaf16, bivalent glue, targeted protein degradation, tpd, transcription
• Biological source: Homo sapiens; More
• Total number of polymer chains: 3
• Total formula weight: 165772.12

Authors

Cowan, A.D.,Sundaramoorthy, R.,Nakasone, M.A.,Ciulli, A. (deposition date: 2023-04-25, release date: 2023-05-17, Last modification date: 2024-03-13)

• Primary citation: Hsia, O.,Hinterndorfer, M.,Cowan, A.D.,Iso, K.,Ishida, T.,Sundaramoorthy, R.,Nakasone, M.A.,Imrichova, H.,Schatz, C.,Rukavina, A.,Husnjak, K.,Wegner, M.,Correa-Saez, A.,Craigon, C.,Casement, R.,Maniaci, C.,Testa, A.,Kaulich, M.,Dikic, I.,Winter, G.E.,Ciulli, A.; Targeted protein degradation via intramolecular bivalent glues.; Nature, 627:204-211, 2024; PubMed: 38383787; DOI: 10.1038/s41586-024-07089-6

Experimental method

ELECTRON MICROSCOPY (3.77 Å)