8OV6
Ternary structure of intramolecular bivalent glue degrader IBG1 bound to BRD4 and DCAF16:DDB1deltaBPB
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DDB1deltaBPB | polymer | 836 | 93347.1 | 1 | Pfam (PF10433) Pfam (PF03178) UniProt (by SIFTS) (Q16531) | Homo sapiens | |
| 2 | B (B) | DDB1- and CUL4-associated factor 16 | polymer | 218 | 24333.4 | 1 | UniProt (Q9NXF7) Pfam (PF15349) | Homo sapiens (human) | |
| 3 | C (C) | Bromodomain-containing protein 4 | polymer | 419 | 47203.2 | 1 | UniProt (O60885) Pfam (PF00439) | Homo sapiens (human) | Protein HUNK1 |
| 4 | D (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | E (C) | methyl 2-[(9~{S})-7-[4-[4-[[4-[(3-cyano-4-methyl-1~{H}-indol-7-yl)sulfamoyl]phenyl]methylcarbamoyl]phenyl]phenyl]-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoate | non-polymer | 823.0 | 1 | Chemie (U79) |
Sequence modifications
B: 1 - 216 (UniProt: Q9NXF7)
C: 42 - 459 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Gly 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 41 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 164883.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 888.4 | |
| All* | Total formula weight | 165772.1 |
