8OTO

SARS-CoV-2 nsp10-16 methyltransferase in complex with AMP

Summary for 8OTO

• Entry DOI: 10.2210/pdb8oto/pdb
• Related: 8BSD 8BZV 8C5M 8OSX 8OT0
• Descriptor: 2'-O-methyltransferase nsp16, Non-structural protein 10, 1,2-ETHANEDIOL, ... (8 entities in total)
• Functional Keywords: methyltransferase, protein complex, inhibitor, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2; More
• Total number of polymer chains: 2
• Total formula weight: 51456.71

Authors

Kremling, V.,Sprenger, J.,Oberthuer, D. (deposition date: 2023-04-21, release date: 2023-05-03, Last modification date: 2024-11-13)

• Primary citation: Kremling, V.,Falke, S.,Fernandez-Garcia, Y.,Ehrt, C.,Kiene, A.,Klopprogge, B.,Scheer, E.,Barthels, F.,Middendorf, P.,Kuhn, S.,Gunther, S.,Rarey, M.,Chapman, H.N.,Oberthur, D.,Sprenger, J.; SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug discovery; Elife, 2024; DOI: 10.7554/elife.98310.1

Experimental method

X-RAY DIFFRACTION (1.8 Å)