8ORV

Crystal structure of monkeypox virus poxin in complex with the STING agonist MD1203

8ORV の概要

• エントリーDOI: 10.2210/pdb8orv/pdb
• 分子名称: MPXVgp165, 9-[(1~{S},6~{R},8~{R},9~{R},10~{R},15~{R},17~{R},18~{R})-8-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-1~{H}-purin-6-one (3 entities in total)
• 機能のキーワード: mpox, monkeypox, virus, poxin, viral protein
• 由来する生物種: Monkeypox virus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23171.30

構造登録者

Duchoslav, V.,Klima, M.,Boura, E. (登録日: 2023-04-17, 公開日: 2023-12-20, 最終更新日: 2024-04-17)

• 主引用文献: Klima, M.,Dejmek, M.,Duchoslav, V.,Eisenreichova, A.,Sala, M.,Chalupsky, K.,Chalupska, D.,Novotna, B.,Birkus, G.,Nencka, R.,Boura, E.; Fluorinated cGAMP analogs, which act as STING agonists and are not cleavable by poxins: Structural basis of their function.; Structure, 32:433-, 2024; PubMed: 38325369; DOI: 10.1016/j.str.2024.01.008

実験手法

X-RAY DIFFRACTION (1.65 Å)