8OQV

Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with Fragment-M-109

Summary for 8OQV

Entry DOI	10.2210/pdb8oqv/pdb
Descriptor	3-hydroxyacyl-CoA dehydrogenase, Putative acyltransferase Rv0859, GLYCEROL, ... (6 entities in total)
Functional Keywords	fatty acid beta oxidation complex, mycobacterium tuberculosis, tfe, fragment screening, substrate channeling, oxidoreductase
Biological source	Mycobacterium tuberculosis H37Rv More
Total number of polymer chains	4
Total formula weight	244171.79
Authors	Dalwani, S.,Wierenga, R.K.,Venkatesan, R. (deposition date: 2023-04-12, release date: 2024-01-24, Last modification date: 2024-07-24)
Primary citation	Dalwani, S.,Metz, A.,Huschmann, F.U.,Weiss, M.S.,Wierenga, R.K.,Venkatesan, R. Crystallographic fragment-binding studies of the Mycobacterium tuberculosis trifunctional enzyme suggest binding pockets for the tails of the acyl-CoA substrates at its active sites and a potential substrate-channeling path between them. Acta Crystallogr D Struct Biol, 2024 Cited by PubMed: 39012716 DOI: 10.1107/S2059798324006557 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.78 Å)

Structure validation