8OQP

Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with Fragment-M-76

Summary for 8OQP

Entry DOI	10.2210/pdb8oqp/pdb
Descriptor	3-hydroxyacyl-CoA dehydrogenase, Putative acyltransferase Rv0859, SULFATE ION, ... (6 entities in total)
Functional Keywords	fatty acid beta oxidation complex, mycobacterium tuberculosis, tfe, fragment screening, substrate channeling, oxidoreductase
Biological source	Mycobacterium tuberculosis H37Rv More
Total number of polymer chains	4
Total formula weight	247646.12
Authors	Dalwani, S.,Wierenga, R.K.,Venkatesan, R. (deposition date: 2023-04-12, release date: 2024-01-24)
Primary citation	Dalwani, S.,Metz, A.,Huschmann, F.U.,Weiss, M.S.,Wierenga, R.K.,Venkatesan, R. Crystallographic fragment binding studies of the Mycobacterium tuberculosis trifunctional enzyme suggest binding pockets for the tails of the acyl-CoA substrates at its active sites and a potential substrate channeling path between them Biorxiv, 2024 Cited by DOI: 10.1101/2024.01.11.575214 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.18 Å)

Structure validation