8OOG

Crystal structure of human MAT2a with S-Adenosylmethionine and a fragment bound in a novel pocket

8OOG の概要

• エントリーDOI: 10.2210/pdb8oog/pdb
• 分子名称: S-adenosylmethionine synthase isoform type-2, S-ADENOSYLMETHIONINE, 6-oxidanyl-1,3-benzoxathiol-2-one, ... (5 entities in total)
• 機能のキーワード: methionine adenosyltransferase, s-adenosylmethionine synthetase, fragment screen, allosteric binder, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44658.70

構造登録者

Schimpl, M. (登録日: 2023-04-05, 公開日: 2023-07-12)

• 主引用文献: La Sala, G.,Pfleger, C.,Kack, H.,Wissler, L.,Nevin, P.,Bohm, K.,Janet, J.P.,Schimpl, M.,Stubbs, C.J.,De Vivo, M.,Tyrchan, C.,Hogner, A.,Gohlke, H.,Frolov, A.I.; Combining structural and coevolution information to unveil allosteric sites.; Chem Sci, 14:7057-7067, 2023; PubMed: 37389247; DOI: 10.1039/d2sc06272k

実験手法

X-RAY DIFFRACTION (1.384 Å)