8OOD

Crystal structure of human DCAF1 WD40 repeats (Q1250L) in complex with compound 15

Summary for 8OOD

• Entry DOI: 10.2210/pdb8ood/pdb
• Related: 8OO5
• Descriptor: DDB1- and CUL4-associated factor 1, MAGNESIUM ION, ACETATE ION, ... (6 entities in total)
• Functional Keywords: dcaf1, ligase, compound, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 43874.43

Authors

Schroeder, M.,Renatus, M. (deposition date: 2023-04-05, release date: 2023-05-24, Last modification date: 2024-06-19)

• Primary citation: Schroder, M.,Renatus, M.,Thoma, C.R.; Reinstating targeted protein degradation with DCAF1 PROTACs in CRBN PROTAC resistant settings; Biorxiv, 2023; DOI: 10.1101/2023.04.09.536153

Experimental method

X-RAY DIFFRACTION (1.497 Å)