8OKU

Salt-Inducible Kinase 3 in complex with an inhibitor

8OKU の概要

• エントリーDOI: 10.2210/pdb8oku/pdb
• 分子名称: Serine/threonine-protein kinase SIK3, ~{N}-ethyl-4-[5-[1-(2-hydroxyethyl)pyrazol-4-yl]benzimidazol-1-yl]-2,6-dimethoxy-benzamide (3 entities in total)
• 機能のキーワード: kinase uba inhibitor, signaling protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 81671.01

構造登録者

Flower, T.G.,Leonard, P.M.,Lamers, M.B.A.C.,Mollat, P. (登録日: 2023-03-29, 公開日: 2024-01-10, 最終更新日: 2024-01-24)

• 主引用文献: Temal-Laib, T.,Peixoto, C.,Desroy, N.,De Lemos, E.,Bonnaterre, F.,Bienvenu, N.,Picolet, O.,Sartori, E.,Bucher, D.,Lopez-Ramos, M.,Roca Magadan, C.,Laenen, W.,Flower, T.,Mollat, P.,Bugaud, O.,Touitou, R.,Pereira Fernandes, A.,Lavazais, S.,Monjardet, A.,Borgonovi, M.,Gosmini, R.,Brys, R.,Amantini, D.,De Vos, S.,Andrews, M.; Optimization of Selectivity and Pharmacokinetic Properties of Salt-Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312.; J.Med.Chem., 67:380-401, 2024; PubMed: 38147525; DOI: 10.1021/acs.jmedchem.3c01428

実験手法

X-RAY DIFFRACTION (3.1 Å)