8OJP

Human galectin 1 in complex with inhibitor

Summary for 8OJP

• Entry DOI: 10.2210/pdb8ojp/pdb
• Descriptor: Galectin-1, (2~{R},3~{R},4~{S},5~{R},6~{R})-2-[3,5-bis(chloranyl)-4-fluoranyl-phenyl]sulfanyl-6-(hydroxymethyl)-4-[4-(1,3-thiazol-2-yl)-1,2,3-triazol-1-yl]oxane-3,5-diol, GLYCEROL, ... (4 entities in total)
• Functional Keywords: galectin, ligand, complex, sugar binding, sugar binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 30996.87

Authors

Hakansson, M.,Diehl, C.,Nilsson, U.J.,Zetterberg, F.R.,Peterson, K. (deposition date: 2023-03-24, release date: 2024-06-12)

• Primary citation: Zetterberg, F.R.,Diehl, C.,Hakansson, M.,Kahl-Knutson, B.,Leffler, H.,Nilsson, U.J.,Peterson, K.,Roper, J.A.,Slack, R.J.; Discovery of Selective and Orally Available Galectin-1 Inhibitors.; J.Med.Chem., 66:16980-16990, 2023; PubMed: 38059452; DOI: 10.1021/acs.jmedchem.3c01787

Experimental method

X-RAY DIFFRACTION (1.71 Å)