8OJM

Galectin-3 in complex with 2,6-anhydro-3-deoxy-3-S-(beta-D-galactopyranosyl)-3-thio-D-glycero-D-galacto-heptonamide

Summary for 8OJM

Entry DOI	10.2210/pdb8ojm/pdb
Descriptor	Galectin-3, (2~{R},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxane-2-carboxamide, 1-thio-beta-D-galactopyranose, ... (5 entities in total)
Functional Keywords	sugar binding protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	16177.37
Authors	Tsagkarakou, A.S.,Leonidas, D.D. (deposition date: 2023-03-24, release date: 2023-09-13, Last modification date: 2023-09-20)
Primary citation	Lazar, L.,Tsagkarakou, A.S.,Stravodimos, G.,Kontopidis, G.,Leffler, H.,Nilsson, U.J.,Somsak, L.,Leonidas, D.D. Strong Binding of C -Glycosylic1,2-Thiodisaccharides to Galectin-3─Enthalpy-Driven Affinity Enhancement by Water-Mediated Hydrogen Bonds. J.Med.Chem., 66:12420-12431, 2023 Cited by PubMed: 37658813 DOI: 10.1021/acs.jmedchem.3c00882 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation